Digital Products

platform
THe TxPREDICTOR DIFFERENCE

 

TxPredictor

Competitor 1

Competitor 2

Competitor 3

T Cell Matching

B Cell Matching

Real time calculations

Cloud based

Extensive clinical validation

Easy to use platform

Low resolution typing support

Quality controlled

MODULES

Risk and Acceptable Mismatch Profile

RAMP

The Risk and Acceptable Mismatch Profile (RAMP) module supports informed donor selection, immunosuppression management, and post-transplant monitoring by predicting epitope mismatches at the loci level. It allows users to evaluate how individual mismatches contribute to overall PIRCHE-T2 and PIRCHE-B scores and match an entire donor population to a patient to estimate average immunogenicity scores. With interactive tools and a visual histogram, RAMP makes it easy to assess acceptable mismatches and understand their impact on donor availability. The histogram displays donor frequency by PIRCHE score, making it easier to identify donors with a higher probability of compatibility based on lower immunogenic risk.

T Memory

TMEM

T Memory (Tmem) extends the capabilities of RAMP by modeling T-cell memory responses that standard HLA testing cannot detect. By using "previous immunizer" data, Tmem provides insight into potential post-transplant antibody risks by identifying HLA mismatches the immune system may have encountered before. Tmem distinguishes between typical unacceptable mismatches and those associated with prior immune activation. By comparing these reference peptide sets with common alleles, it identifies overlaps that suggest a memory response. This enables clinicians to avoid re-exposing patients to specific mismatches and to refine their donor selection strategy accordingly.

Outcomes Prediction

The Outcomes Prediction module is the latest enhancement to the PIRCHE TxPredictor platform, available exclusively through our Early Access Program. Designed to provide transplant teams with a more comprehensive understanding of the factors influencing outcome, this module goes beyond HLA molecular matching data to incorporate key clinical variables such as patient age, race, prior transplants, and more. By allowing a deeper look into the individual parameters that affect transplant success, the Outcomes Prediction module supports smarter, more personalized risk prediction.

Donor Selection

The Donor Selection module supports both solid organ and stem cell transplantation by allowing clinicians to compare multiple donors for a single patient using comprehensive immune profiling.

This tool evaluates immunologic compatibility in real time, displaying how each donor's mismatches affect the patient's PIRCHE score. A color-coded heatmap highlights which HLA mismatches most strongly contribute to the total immunogenicity, providing clear visual guidance to support more confident donor selection.

HSCT Search Profile

The HSCT Search Profile is  designed to support hematopoietic stem cell transplant teams in identifying  low-epitope-mismatched HLA combinations—even without access to a full stem  cell donor registry. This module estimates the likelihood of finding a donor with  a low PIRCHE score and presents the data in a combined table and chart view  for fast and intuitive review. It enables transplant professionals to locate  ideal mismatch scenarios quickly and streamline the search for  immunologically compatible donors.

INTEGRATIONS WITH PIRCHE

LIMS integration with Histotrac

Pirche has partnered with HistoTrac LMS Software to provide a streamlined and seamless integration for obtaining PIRCHE scores and optimizing automated non-PHI data exchange directly between the HistoTrac LMS Software and TxPREDICTOR.

MatchX integration with Werfen

Werfen (formally Immucor) and Pirche have partnered to provide customers with next-generation antibody analysis utilizing epitope scoring. The MatchX API solution involves integrating Pirche’s advanced epitope matching technology with Werfen's comprehensive suite of transfusion and transplantation diagnostic solutions.

PIRCHE HLA Interface

If the Histotrac and MatchX API solutions do not meet your needs, we are here to support customized workflows. These tailored APIs ensure smooth data exchange and enhance the efficiency of compatibility assessments by automating the data exchange process.