Pirche

FULL ARTICLE

PUBLISHED BY

Matthias Niemann, Benedict M. Matern, Gaurav Gupta, Bekir Tanriover, Fabian Halleck, Klemens Budde, Eric Spierings.

PUBLISHED IN

Frontiers in Immunology

PATIENTS

N/A

ABSTRACT

HIGHLIGHTS

Multiple molecular HLA compatibility models (Eplets, Snow, PIRCHE-II, amino acid matching) were evaluated for their ability to predict graft survival after kidney transplantation.

Combining these models, particularly HLA matching with Snow and PIRCHE-II, improved prediction performance compared to using individual models or clinical factors alone.

Using multiple molecular HLA matching predictors enhances risk classification and can support better decision-making in kidney transplantation, especially for long-term outcomes.

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back to key milestones

2025

Methods

Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compatibility

PUBLISHED BY

PUBLISHED IN

PATIENTS

ABSTRACT

HIGHLIGHTS

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