PUBLISHED BY
Arwa Kamoun, Rimeh Ben Brahim, Aida Charfi, Soumaya Yaich, Mondher Masmoudi, Faiza Hakim, Lilia Gaddour, Mohamed Ben Hmida, Hafedh Makni, Nadia Mahfoudh
PUBLISHED IN
Human Immunology
PATIENTS
112
ABSTRACT
HIGHLIGHTS
· In a Tunisian kidney transplant population,17% of recipients developed de novo donor-specific antibodies (dnDSA), mostlyagainst HLA-DQ, with a median appearance time of 50 months post-transplant.
· Having a male donor was linked to a lowerrisk of dnDSA, while longer cold ischemia time (the time the organ spendsoutside the body) increased the risk.
· Mismatches in HLA-DQ molecules and higherPIRCHE-II scores were significantly associated with the development of dnDSA.
· Factors associated with reduced graftsurvival included transfusions after transplant, mismatches in the HLA-DRB1region, dnDSA development, and a high PIRCHE-II score.
