PUBLISHED BY
Anne Cathrine Staff, Heidi E Fjeldstad, Maria B Olsen, Jonas Øgaard, Marte K Viken, Cynthia S M Kramer, Michael Eikmans, Thomas Kroneis, Katja Sallinger, Sami B Kanaan, Meryam Sugulle, Daniel P Jacobsen
PUBLISHED IN
HLA
PATIENTS
76
ABSTRACT
HIGHLIGHTS
· Foetal microchimerism, the persistence offoetal cells in mothers, can last decades postpartum, influenced by HLA geneticmismatches.
· Studytrackes foetal microchimerism in 76pregnant women, with 59 monitored up to 8 years postpartum.
· During pregnancy, higher HLA class IImismatch scores correlated with fewer detectable foetal cells.
· Postpartum, greater HLA mismatches,particularly in class I and II, corresponded with reduced foetal microchimerismpresence and quantity.
· Findings suggest maternal immune responsesmay clear foetal cells over time, potentially affecting long-term maternalhealth impacts.
