PUBLISHED BY
Zhuldyz Zhanzak, Aileen C. Johnson, Petra Foster, Maria A. Cardenas, Anna B. Morris, Joan Zhang, Geeta Karadkhele, Raul Badell, Alanna A. Morris, Byron B. Au-Yeung, Fernanda M. Roversi, Juliete A.F. Silva, Cynthia Breeden, Annette Hadley, Weiwen Zhang, Christian P. Larsen, Haydn T. Kissick
PUBLISHED IN
Immunity
PATIENTS
ABSTRACT
HIGHLIGHTS
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Patients with HLA-DQ antibodies have CD4+ T cells targeting HLA-DQ polymorphisms
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H2-Kd287-301 is an indirect CD4+ T cell epitope associated with rejection
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Inducing tolerance to immunodominant indirect CD4+ T cells prolongs graft survival
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Indirect CD4+ T cells maintain a prevalent public and quasi-public TCR repertoire
