PUBLISHED BY
Crane, Clarkson; Niemann, Matthias; Dale, Bethany; Gragert, Loren; Shah, Mita; Ingulli, Elizabeth; Morris, Gerald P.
PUBLISHED IN
PATIENTS
419
ABSTRACT
HIGHLIGHTS
- Retrospective analysis comparing the effectiveness of high resolution (HR) genotyping versus imputed low resolution (LR) genotyping for PIRCHE-II analysis which identifies significant differences in immunologic risk classification.
- Using high resolution (HR) HLA genotyping for PIRCHE-II enhances the accuracy of predicting mismatched donor HLA peptides compared to low resolution (LR) typing data imputation.
- HR typing improves the ability to predict donor-specific antibody development and acute rejection.
- Multiethnic reference populations improve successful imputation rates, reducing unsuccessful imputation from 10% with historic Caucasian references to 1%.
- HR genotyping provides more precise immunologic risk classification, with 20% of patients being differently classified compared to LR genotyping, indicating better risk assessment for transplant recipients.
