PUBLISHED BY
Zhang, Xiaohai; Kransdorf, Evan; Levine, Ryan; Patel, Jignesh K.; Kobashigawa, Jon A.
PUBLISHED IN
Human Immunology
PATIENTS
548
ABSTRACT
HIGHLIGHTS
- Article examines the impact of HLA mismatches in eight HLA loci on the development of dnDSA and on rejection in a large cohort of heart transplant recipients.
- HLA mismatches evaluated at the antigen level, the eplet level using HLAMatchmaker, and the epitope level using the PIRCHE algorithm.
- Majority of dnDSA were found to be against HLA-DQ antigens, and the number of dnDSA per mismatch is highest for HLA-DQ compared to other HLA loci.
- Mismatches of HLA-DQ at the epitope level were associated with antibody-mediated rejection.
- Results suggest that HLA mismatches at the HLA-DQ locus are more immunogenic than mismatches at other HLA loci to stimulate the development of dnDSA and to cause graft rejection.
