PUBLISHED BY
Santos, Eva; Spensley, Katrina; Gunby, Nicola; Worthington, Judith; Roufosse, Candice; Anand, Arthi; Willicombe, Michelle
PUBLISHED IN
American Journal of Transplantation
PATIENTS
419
ABSTRACT
HIGHLIGHTS
- Utilizing PIRCHE-II alongside HLA-Matchmaker and HLA-EMMA enhances the prediction of de novo donor-specific antibody (dnDSA) occurrence post-kidney transplant, particularly in patients managed with a steroid-sparing immunosuppression protocol.
- Elevated PIRCHE-II molecular mismatch (MolMM) loads significantly correlate with increased risk of dnDSA development, highlighting its importance in identifying immunological risk.
- Ethnic variations impact PIRCHE-II MolMM loads, underscoring the necessity for considering immunogenicity across diverse patient populations to better predict alloimmune responses.
- Integration of PIRCHE-II MolMM assessment aids in pinpointing recipients at lower risk of dnDSA while undergoing minimalist immunosuppression, facilitating personalized risk stratification.
- Immunogenic eplets identified through PIRCHE-II analysis serve as potential targets for antibody responses, emphasizing the need for further investigation into immunogenicity alongside MolMM load assessment, especially in diverse ethnic groups and under varied immunosuppression regimens.
