PUBLISHED BY
Hiho, Steven J.; Levvey, Bronwyn J.; Diviney, Mary B.; Snell, Gregory I.; Sullivan, Lucy C.; Westall, Glen P.
PUBLISHED IN
American Journal of Transplantation
PATIENTS
277
ABSTRACT
HIGHLIGHTS
- Despite advances in sequencing technology and immunological compatibility algorithms, outcomes in lung transplantation remain suboptimal, and there is no consensus on the best HLA compatibility approach.
- Retrospective study of 277 donor-recipient pairs using Next Generation Sequencing. Lower HLA class II mismatching, as determined by various tools including PIRCHE, was associated with improved survival (p<0.05), highlighting the potential significance of PIRCHE in predicting lung transplant outcomes.
- Study suggests that reducing HLA mismatching in different aspects (T- or B-cell epitopes, electrostatic differences, or amino acids) can enhance lung transplant outcomes, offering the possibility of personalized immunosuppression strategies based on specific HLA compatibility tools.
