PUBLISHED BY
Takeshi Sugio, Kohta Miyawaki, Naoyuki Uchida, Matthias Niemann, Eric Spierings, Kyohei Mori, Yuju Ohno, Tetsuya Eto, Yasuo Mori, Goichi Yoshimoto, Yoshikane Kikushige, Yuya Kunisaki, Shinichi Mizuno, Koji Nagafuji, Hiromi Iwasaki, Tomohiko Kamimura, Ryosuke Ogawa, Toshihiro Miyamoto, Shuichi Taniguchi, Koichi Akashi, Koji Kato
PUBLISHED IN
British Journal of Haematology
PATIENTS
1498
ABSTRACT
HIGHLIGHTS
· Cord blood transplantation (CBT) offersan alternative donor source with lower graft-versus-host disease risk and lessstringent HLA matching but higher transplantation-related mortality (TRM).
· Researchers proposed that analyzing theimmunogenicity of mismatched HLA could uncover harmful, non-permissivemismatches contributing to increased TRM.
· A retrospective analysis of 1,498 CBTcases (2000–2018) using the PIRCHE algorithm found that mismatched HLA-B ClassI epitopes, especially from exon 1 with M-type leader peptides, were linked tohigher TRM and poorer neutrophil engraftment.
· Immunogenicity-based donor selection,considering specific HLA-B epitope mismatches, could improve CBT outcomes.
