PUBLISHED BY
Liseanne J. van’t Hof, Marie-Louise P. van der Hoorn, Selena Migdis, Geert W. Haasnoot, Emma T. M. Peereboom, Eric Spierings, Pieter J. E. van der Linden, Jacqueline D. H. Anholts, Heleen de Vreede, Winnie Ottenhof, Dave L. Roelen, Michael Eikmans, Inge B. Mathijssen, Lisa E. E. L. O. Lashley
PUBLISHED IN
HLA
PATIENTS
262
ABSTRACT
HIGHLIGHTS
- HLA-DQB1 Mismatching Linked to Hypertensive Complications
Pregnancies with hypertensive complications (PIH and pre-eclampsia) showed a significantly higher number of maternal–foetal HLA-DQB1 mismatches than expected by chance, in contrast to uncomplicated pregnancies.
- PIRCHE-II Analysis Supports Immunogenic Role
Predicted indirectly recognisable epitopes (via the PIRCHE-II algorithm) were elevated for HLA-DQB1 and HLA class II in hypertensive pregnancies, suggesting increased potential for T-cell mediated immune activation.
- Evidence of Preferential HLA Matching in Uncomplicated Pregnancies
In this genetically isolated Dutch population, uncomplicated pregnancies showed no preferential selection for maternal–foetal HLA matching, indicating that compatibility alone does not determine healthy pregnancy outcomes.
- KIR/HLA-C Combinations Not Associated With Outcomes
Maternal KIR receptor and foetal HLA-C genotype combinations did not differ significantly between uncomplicated and hypertensive pregnancies, highlighting HLA-DQB1 as the more critical locus in this context.
