PUBLISHED BY
Rima M. Saliba, Matthias Niemann, Samer A. Srour, Uri Greenbaum, Kamal K. Alzahrani, Yudith Carmazzi, Gabriela Rondon, Katayoun Rezvani, May Daher, Dan Li, Qing Ma, Mark R. Tanner, Kai Cao, Elizabeth J. Shpall, Richard E. Champlin, Eric Spierings, Jun Zou
PUBLISHED IN
Transplantation and Cellular Therapy
PATIENTS
712
ABSTRACT
HIGHLIGHTS
- HY Antigen Disparity Influences Outcomes
In female-to-male stem cell transplants, greater HY mismatch (measured by PIRCHE scores) was linked to more severe acute GVHD and higher relapse risk.
- Distinct T-cell Pathways Play Different Roles
High PS-I scores (CD8⁺ T-cell related) correlated with acute GVHD and relapse, while high PS-II scores (CD4⁺ T-cell related) were associated with lower relapse but more chronic GVHD.
- Risk Profiles Help Stratify Patients
In this genetically isolated Dutch population, uncomplicated pregnancies showed no A high PS-I/low PS-II profile predicted higher relapse and worse progression-free survival, whereas a low PS-I/high PS-II profile increased chronic GVHD risk but showed a trend toward improved outcomes.
- KIR/HLA-C Combinations Not Associated With Outcomes
Maternal KIR receptor and foetal HLA-C genotype combinations did not differ significantly between uncomplicated and hypertensive pregnancies, highlighting HLA-DQB1 as the more critical locus in this context.
