Pirche

PUBLISHED BY

Maria Christine Krog, Emma T. M. Peereboom, Kirsten Geneugelijk, Benedict M. Matern, Astrid Marie Kolte, Ole Bjarne Christiansen, Rudi Steffensen, Henriette Svarre Nielsen, Eric Spierings

PUBLISHED IN

HLA

PATIENTS

ABSTRACT

HIGHLIGHTS

Recurrent pregnancy loss (RPL) affects 1%-3% of women, with secondary RPL (sRPL) occurring after a live birth.

Immune factors may contribute to RPL, though underlying causes are unclear.

A study found that sRPL mothers with anti-HLA antibodies and higher PIRCHE-II scores had more live births in a placebo group.

Overlapping peptides from paternal haplotypes correlated with live births, suggesting immune compatibility may impact outcomes.

Findings highlight immune interactions as potential targets for personalized diagnosis and treatment in sRPL.

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2024

Pregnancy

Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial

PUBLISHED BY

PUBLISHED IN

PATIENTS

ABSTRACT

HIGHLIGHTS

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