PUBLISHED BY
Daniëls, Beeckmans, Zajacova, Kerckhof, Bos, Naesens, Vanaudenaerde, Claas, Vos
PUBLISHED IN
Transplant International
PATIENTS
128
ABSTRACT
HIGHLIGHTS
· Higher HLA-DQB1 mismatch scores, calculated byHLA-EMMA and PIRCHE-II, were linked to faster development of donor-specificantibodies (DSA) after lung transplant.
· Higher HLA-EMMA DQB1 mismatch scores wereassociated with worse patient survival after lung transplant.
· The presence of two KIR ligand Host-versus-Graft(HvG) mismatches was linked to a shorter time to the first rejection episodeand worse graft survival.
· HLA-DQB1 and KIR mismatch scores could helpidentify lung transplant recipients at higher risk of DSA formation, rejection,and poor outcomes, potentially informing treatment decisions.
